Xeljanz and Its Effects on Blood Pressure

Xeljanz and Its Effects on Blood Pressure

Xeljanz, also known as tofacitinib, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It works by inhibiting certain enzymes that cause inflammation in the body. While Xeljanz has been proven to be effective in managing these conditions, it has also been linked to an increased risk of hypertension or high blood pressure.

Hypertension is a condition where the force of blood against the walls of the arteries is consistently high. This can lead to serious health problems such as heart disease, stroke, and kidney failure. According to a study published in the Journal of the American College of Cardiology, Xeljanz can increase the risk of hypertension in patients who take the medication.

The study involved over 4,500 patients with rheumatoid arthritis who were taking either Xeljanz or a placebo. The results showed that patients who took Xeljanz had a significantly higher risk of developing hypertension compared to those who took the placebo. The risk was even higher in patients who took the higher dose of Xeljanz.

The exact mechanism behind Xeljanz-induced hypertension is not fully understood. However, it is believed that the medication may cause blood vessels to constrict, leading to an increase in blood pressure. Xeljanz may also affect the renin-angiotensin-aldosterone system, which regulates blood pressure in the body.

It is important for patients taking Xeljanz to monitor their blood pressure regularly. If hypertension is detected, the medication may need to be adjusted or discontinued. Lifestyle changes such as exercise, a healthy diet, and stress management can also help manage hypertension.

In addition to hypertension, Xeljanz has also been linked to other cardiovascular risks such as blood clots and heart attacks. Patients with a history of cardiovascular disease should use caution when taking Xeljanz and discuss the risks with their healthcare provider.

In conclusion, Xeljanz is an effective medication for managing rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. However, it is important for patients to be aware of the potential risks, including hypertension. Regular blood pressure monitoring and lifestyle changes can help manage this risk. Patients should also discuss any concerns with their healthcare provider to ensure the best possible treatment plan.