Antianginal Drugs_ Pharmacology Overview

Antianginal Drugs: Pharmacology Overview

Slide 1: Introduction to Antianginal Drugs

Definition of angina pectoris

Pathophysiology: Imbalance between myocardial oxygen supply and demand

Goals of antianginal therapy

Slide 2: Classification of Antianginal Drugs

Organic Nitrates

Beta-Adrenergic Blockers

Calcium Channel Blockers

Novel Agents

Slide 3: Organic Nitrates

Mechanism of Action: NO donors 鈫?鈫?cGMP 鈫?Vasodilation

Examples: Nitroglycerin, Isosorbide mononitrate, Isosorbide dinitrate

Pharmacokinetics: Rapid onset, short duration (sublingual), longer for oral/transdermal

Clinical Uses: Acute relief and prophylaxis of angina

Slide 4: Beta-Adrenergic Blockers

Mechanism: Block 尾1 receptors 鈫?鈫?HR, contractility, BP

Examples: Metoprolol, Atenolol, Propranolol

Pharmacokinetics: Oral absorption, hepatic metabolism

Clinical Uses: First-line for chronic stable angina, post-MI

Slide 5: Calcium Channel Blockers (CCBs)

Mechanism: Block L-type Ca2+ channels 鈫?Vasodilation, 鈫?contractility

Types: Dihydropyridines (e.g., Amlodipine) vs. Non-dihydropyridines (e.g.